教师详情-凯发ag旗舰厅登录

一.获批项目：

1.基于调控微生物代谢能耗的硝基苯降解调控开关的研究.甘肃省自然科学基金青年基金.2020/10-2022/11.

2.亚硝酸盐还原酶转录调控蛋白nsrr去阻遏机制研究.国家自然科学基金青年基金.2017/01-2019/12.

一. 教学情况：

1.本科生《微生物工程》《发酵工程实验》《合成生物学》

2.研究生《高级生物生物信息学》《论文写作指导与专业外语》

二. 指导研究生情况：

1.合作指导硕士研究生4人（毕业2人，在读2人，发表sci 4篇），

2.合作指导博士研究生2人（在读，sci2篇）；

1.发酵工程：

微生物资源开发与利用；功能微生物机理验证及应用开发；混菌发酵模拟及其机制解析；

2 酶工程：

微生物源胰蛋白酶分子改造，几丁质降解酶系开发及利用；微生物负调控蛋白分子改造；

一. 一作及通讯作者文章：

(1).yanli chen, zhenmin ling(#), xing wang, simin zong, jinfeng yang, qing zhang,jing zhang, xiangkai li(*).the beneficial mechanism of chitosan and chitooligosaccharides in the intestine on different health status.journal of functional foods, 2022,97:105232.

(2)yanli chen,zhenmin ling(#),tursunay mamtimin,aman khan,liang peng,jinfeng yang, gohar ali,tuoyu zhou,qing zhang,jing zhang,xiangkai li(*).chitooligosaccharides production from shrimp chaff in chitosanase cell surface display system.carbohydrate polymers.2022,277:118894.

(3)gohar ali,zhenmin ling(#)(*),irfan saif,muhammad usman,mohammed jalalah,farid a.harraz,m.s.al-assiri,el-sayed salama,xiangkai li.biomethanation and microbial community response during agricultural biomass and shrimp chaff digestion.environmental pollution.2021,278:116801.

(4)zhenmin ling(#),nandini thakur,marwa m.el-dalatony,el-sayed salama(*),xiangkaili1(*),protein biomethanation:insight into the microbial nexus.trend in microbiology.2022,30(1):69-78.

(5)huawenhana,zhenmin ling(#),aman khan,amanpreet kaur virk,saurabh kulshrestha,xiangkai li(*).improvements of thermophilic enzymes:from genetic modifications to applications.bioresourcetechnology.2019.279:350-361.

(6)ning yang, zhenmin ling(#),liang peng,yanlai liu,pu liu,kai zhang,aman khan,juanjuan shi1,xiangkai li(*).improvement of enzymatic stability and catalytic efficiency of recombinant fusarium oxysporum trypsin with different n-terminal residues produced by pichia pastoris.journal of microbiology and biotechnology.2018,28(9):1482-1492.

(7)yuefeng zhang(#),zhenmin ling(#),guocheng du(*),jian chen,zhen kang(*).improved production of active streotomyces griseus trypsin with a novel auto-catalyzed strategy. scientfic reports.2016,6:2158.  doi:10.1038/srep23158

(8)zhenmin ling(#),zhen kang(*),yi liu,song liu,jian chen,guocheng du(*).improvement of catalytic efficiency and thermotability of recombinant streptomyces griseus trypsin by introducing artificial propeptide. world journal of microbiology and biotechnology.2014,30(6):1819-1827.

(9)ling zhenmin(#),liu yi,teng shaolei,kang zhen(*),zhang jingjing,chen jian,du guocheng(*).rational design of a novel propeotide for improving active production of steptomyces griseus trypsin in pichia pastoris. applied and environmental microbiology.2013,79(12):3851-3855.

(10)ling zhenmin(#),ma tengbo,li jianghua,du guocheng,kang zhen(*),chen jian(*).functonal expression of trypsin from streptomyces griseus by pichia pastoris. journal of industrial microbiology and biotechnology.2012,39(11):1651-1662.

二. 其他论文

(1)jinfeng yang, pengya feng, zhenmin ling(#), aman khan , xing wang,yanli chen, gohar ali, yitian fang, el-sayed salama, ximei wang, pu liu(*), xiangkai li(*).nickel exposure induces gut microbiome disorder and serum uric acid elevation. environmental pollution.2023,324:121349.

(2)rong han,aman khan,zhenmin ling,ying wu,pengya feng,tuoyu zhou,el-sayed salama,marwa m. el-dalatony,xirong tian,pu liu(*),xiangkai li.feed-additive limosilactobacillus fermentum gr-3 reduces arsenic accumulation in procambarus clarkii.ecotoxicology and environmental safety.2022,231:113216.

(3)pengya feng,ze ye,huawen han,zhenmin ling,tuoyu zhou,shuai zhao,amanpreet kaurvirk,apurva kakade,abdel-fatah abomohra,marwa m.el-dalatony,ei-sayed salama,pu liu1(*),xiangkai li(*).tibet plateau probiotic mitigates chromate toxicity in mice by alleviating oxidative stress in gut microbiota.communication biology.2020,3:242.

(4)junjiao zhang,zhen kang(*),zhenmin ling,wenlong cao,long liu,miao wang,guocheng du,jian chen(*).high-level extracellular production of alkaline polygalcturonate lyase in bacillus subtilis with optimized regulatoy elements.bioresource technology.2013,146:543-548.

(5)马腾博，令桢民，康振，李江华，堵国成，陈坚(*).灰色链霉菌胰蛋白酶在变铅青链霉菌中的异源表达及酶学性质分析.生物工程学报.2013,9(4):466-479.